《我女友是九尾狐》講述的是一隻沉睡了500年的九尾狐（申敏兒飾）偶然從封印中解脫出來後與人類男子（李升基飾）同居而發生的喜劇故事。將古典色彩的九尾狐用現代的方式重新詮釋，與現存九尾狐的形象完全不同“九尾狐”一角是這部連續劇的最大看點。

Cha Dae Woong (Lee Seung-ki) meets a girl (Shin Min-ah) and falls in love with her. The girl is actually a Gumiho, a legendary fox with nine tails that eats the livers of humans. When he finds out that she is a Gumiho, he ends up doing crazy things to prevent the girl from eating his liver.